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The SAVOR-TIMI 53 (Saxagliptin Assessment of Vascular Outcomes Recorded in Patients with Diabetes Mellitus-Thrombolysis in Myocardial Infarction) trial with saxagliptin suggested an increased risk for incident heart failure (73)
This would involve the assessment of multiple investigational therapies at one time with a shared placebo group, and frequent interim analyses to determine which treatments were working and warrant transition from Phase 2 to Phase 3 testing
Will 2.5 mg Retatrutide Activate the Glucagon Receptor
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DSIP recovered motor function in rats after focal stroke in a 2021 study (PMID 34500605), and a phosphorylated DSIP variant restored spatial memory and p-CREB expression in a high-altitude model (PMID 30107169)
