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Quercetin enhances adriamycin cytotoxicity through induction of apoptosis and regulation of mitogen-activated protein kinase/extracellular signal-regulated kinase/c-Jun N-terminal kinase signaling in multidrug-resistant leukemia K562 cells

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Crucially, FOXO4 knockdown significantly reduced the viability of senescent TM3 Leydig cells and substantially increased their rate of apoptosis