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Tissue Engineering in Achilles Tendon Reconstruction

In particular, respiratory viral infections were shown to be associated with inhibition of Nrf2 and activation of the nuclear factor-kappa B (NF-B) pathway, leading to increased oxidative damage and promoting inflammation [29, 30]

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Despite this significant effect, doxycycline is unsuitable for implementation in mass drug administration (MDA) programs due to the logistics of delivering a relatively long course of treatment and its contraindication in pregnancy, during breastfeeding and in children below the age of 8 years old (Taylor et al., 2013a)