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I-BET151 (a selective inhibitor of BET) can reduce joint inflammation and bone loss by blocking MMP-1, MMP-3, IL-6, and IL-8 production in RA FLS (190, 306)

Typical dosages range from: 200 mcg to 500 mcg per day for minor injuries Up to 1,000 mcg per day for more serious cases Duration of therapy generally spans 2 to 4 weeks, though some protocols extend longer depending on the severity of the condition

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Always consult a healthcare professional before starting supplements.