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modulation of DNA-repair, antioxidant, and proteasome-related gene clusters

Metformin is FDA-approved as a diabetes drug and sometimes prescribed off-label for weight loss

The relationship between weight loss and cholesterol improvement is direct and measurable

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Each protocol outlines the study rationale and design following the HARmonized Protocol Template to Enhance Reproducibility (HARPER), a structured framework for transparent and reproducible observational study design 44