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Endocrinology 148 (10), 46584666
How do you know if you need vitamin B12 shots
A 12-week randomized trial demonstrated: Average weight loss of 2.6 kg in AOD-9604 group (1 mg/day) versus 0.8 kg in placebo group Preferential reduction in abdominal and visceral fat deposits No adverse effects on carbohydrate metabolism or insulin sensitivity Non-dose-dependent effects, with higher doses (10 mg/day) producing less weight loss than lower doses However, a subsequent 24-week Phase III trial with 502 subjects incorporating intensive diet and exercise showed no statistically significant weight loss compared to placebo, leading to development termination in 2007
Continue Reading How long does a B12 shot last and stay in your system
Published human trials mainly studied oral and intravenous forms, so subcutaneous amounts come from community practice rather than an approved clinical protocol
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