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This dual action may make Mounjaro more effective for weight loss and blood glucose control in comparison with other GLP-1 medications that target only one receptor (GLP-1), like Ozempic and Wegovy
| doi:10.1007/s10545-007-0666-z Constantin-Teodosiu D, Carlin JI, Cederblad G, Harris RC, Hultman E: Acetyl group accumulation and pyruvate dehydrogenase activity in human muscle during incremental exercise (1991) Acta Physiol Scand | doi:10.1111/j.1748-1716.1991.tb09247.x Diamanti K, Cavalli M, Pan G, et al.: Intra- and inter-individual metabolic profiling highlights carnitine and lysophosphatidylcholine pathways as key molecular defects in type 2 diabetes
The Pharmaceutical Journal states explicitly: "There is no validated dose equivalence between the two agents owing to their differing receptor profiles." Even patients who were stable on semaglutide 2.4mg (Wegovy maximum) must begin tirzepatide at 2.5mg once weekly and titrate per the standard schedule
[4] [5] The GLP-1 component works by stimulating insulin secretion in a glucose-dependent manner, suppressing glucagon release, and reducing appetite through central nervous system pathways
doi: 10.1111/cns.13212 48
