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Apovian CM, Aronne LJ, Bessesen DH, et al

For a brief description, GLP-1RAs attenuate and stabilize the development of atherosclerotic plaques through anti-inflammatory mechanisms and preventing vascular remodeling, and inhibit activation and recruitment of macrophages in atherosclerosis

These include: Subcutaneous injections , like Wegovy and Ozempic Oral tablets, like Rybelsus Subcutaneous semaglutide Both Wegovy and Ozempic are injected subcutaneously on a weekly basis , under the skin of the thigh, abdomen, or upper arm

Blood sugar crashescalled hypoglycemiapose the most serious risk, potentially causing confusion, loss of consciousness, or seizures if glucose levels drop below 54 mg/dL

Importantly, renal and hepatic impairment do not meaningfully alter tirzepatide pharmacokinetics, and no dose adjustments are required for patients with kidney or liver disease