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Preclinical studies in diet-induced obesity models demonstrated 5-Amino-1MQ reduced body weight by 7% and increased energy expenditure by 9% over 11 days without dietary changes

Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high-fat-diet-induced obesity in mice

Fourteen improved, and 7 of 12 reported durable improvement beyond six months by telephone follow-up

Clinical Status: 5-Amino-1MQ is a research compound evaluated in preclinical and emerging human studies for obesity, insulin resistance, and metabolic health applications