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Sigma-1 receptor chaperone at the ER-mitochondrion interface mediates the mitochondrion-ER-nucleus signaling for cellular survival

C., Gallo, R

This contributes to injury recovery and has the potential to boost cardiovascular health, increasing circulation and stabilizing blood pressure [33, 34, 35]

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In other tissues, including the liver, skeletal muscle and macrophages, genetic disruption of clock genes has also been linked to changes in CI, CII and CIII respiration 6,37,38,39,40,41,42,43 , highlighting that clock regulation of mitochondrial function is shaped by cell type and metabolic state