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Systolic (SBP) and diastolic blood pressure (DBP) were also consistently reduced by incretin-based drugs, ranging from 3.1 and 0.57 mmHg with liraglutide 3.0 mg to 9.2 and 5.1 mmHg with retatrutide, respectively
Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist approved by the FDA for managing type 2 diabetes mellitus and chronic weight management
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There was a consistent reduction in pain using the WOMAC pain subscale and about 15% of patients reported being pain free by the end of the trial
A study suggested also that the use of a BP-lowering central sympatholytic drug, moxonidine, might induce a small but significant weight loss, together with a reduction in blood pressure, triglycerides and fasting blood glucose (Chazova and Schlaich, 2010)
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