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& Kerksick, C

The Wilcoxon rank-sum test was used to determine the pairwise statistical difference in mean changes among the study groups

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Unlike semaglutide which solely activates GLP-1R (one of the three pivotal receptors regulating glucose homeostasis), tirzepatide also activates glucose-dependent insulinotropic polypeptide (GIP) receptor (GIPR) to enhance metabolic benefits with reduced side-effects 5

Tesamorelin drives body composition changes through metabolic and hormonal shifts