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Despite their therapeutic potential, challenges such as large-scale production, safety assessment, and mechanistic understanding remain to be addressed for their clinical application

Personal or family history of medullary thyroid carcinoma (MTC)

[327] It is also a common trigger for rosacea flare-ups, a skin condition that can affect the eyes, leading to redness and irritation

Other benefits, such as reduced inflammation and improved digestion, often become more apparent with consistent use over time

Thus, whereas KEAP1 is a sulfur-utilizing sensor, NRF2 is a sulfur-regulating effector, both together comprising a sulfur-employing defense mechanism