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2.3.1 Cognitive impairment METH abuse significantly impairs cognitive function by targeting key brain regions (McCann et al., 2008), such as the hippocampus, striatum, amygdala, and prefrontal cortex

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the weight in kilograms divided by the square of the height in meters) of 30 or higher, or of 27 or higher with at least one obesity-related complication, and at least one participant-reported unsuccessful dietary effort to lose weight were randomly assigned, in a ratio of 21:3:3:7, to receive for 68 weeks the fixed-dose combination of cagrilintidesemaglutide (2.4 mg of each drug) administered subcutaneously once weekly, semaglutide alone at a dose of 2.4 mg, cagrilintide alone at a dose of 2.4 mg, or placebo, in addition to lifestyle intervention

Sodium chloride 0.9% (normal saline) contains sterile water and sodium chloride (salt) to create an isotonic solution

The key is understanding the relationship between concentration and volume