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Although numerous anti-depressive treatments are available, 30% of patients diagnosed with depression do not experience positive therapeutic effects with these therapies ( The gut is a key member of the gut-brain axis owing to its own enteric nervous system and its independent responses to the exterior environment and stress (Rao and Gershon, 2016)

Nausea may be due to delayed gastric emptying, and abdominal distention and constipation may be due to delayed intestinal motility, but the reason for the diarrhea is unclear

This medication was first approved by the FDA in December 1998

For diabetes management, the target HbA1c is typically below 7% for most adults, though individualized targets may be appropriate based on age, comorbidities, and hypoglycemia risk