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FIGURE 7 To establish if the Y296 residue serves to shield the FAD from non-specific reduction, both the U597C and Y296A variants were mixed with millimolar concentrations of dithionite under anaerobic conditions (Figure 7A inset)

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doi: 10.1056/NEJMoa2028395 131 BolandMLLakerRCMatherKNawrockiAOldhamSBolandBBet al

Both GLP-1 and GIP have been shown to regulate appetite and enhance memory formation with a high expression of GIP in neurons within the hippocampus, olfactory bulb, and Purkinje cells of the cerebellum [100]