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An FXR agonist, obeticholic acid, is the first molecule to deliver a statistically significant improvement in one of the FDAs surrogate endpoints for accelerated approval of a treatment for NASH

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The analysis included a detailed examination of the levels of messenger RNA (mRNA) for enzymes involved in the liver's urea cycle

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Bottom line: Taking these antioxidants on an empty stomach in the morning maximizes their path to the bloodstream and sets a baseline for cellular protection throughout the day

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doi:10.1016/j.smrv.2016.06.005

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