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Around 0.51% of patients developed gallbladder-related issues in trials

A recent review by Gatto et al., published in May 2025, reached a similar conclusionsuggesting that GLP-1 receptor agonists may have a positive impact on musculoskeletal health

if you have a medical emergency, call 911

Here is how to think about it: What is normal during titration Mild nausea that comes and goes, especially in the first 35 days after a dose increase Reduced appetite this is the medication working as intended Occasional loose stools or minor constipation Mild fatigue or low energy as your caloric intake decreases Slight bloating or feeling full faster than usual These effects are typically self-limiting