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Retatrutide Research# The pivotal Phase 2 trial (338 participants, NEJM 2023) showed 24.2% weight loss at 48 weeks

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Use of these drugs is associated with a lower risk of hypoglycemia, when compared to insulin, sulfonylureas and thiazolidinediones [41, 42]

However, weight loss is a well-documented secondary effect, and many providers prescribe Ozempic off-label specifically for its weight management benefits

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