And second, I have some friends who are really into meat, and I like meat a lot
and even as they account for less than 1% of the intestinal epithelium, they establish a complex signaling network, that is likely to be the first step of integration, involving the information obtained from the gut lumen (63, 88, 89)
Of these patients, a large proportion initiating oral semaglutide (36.1%) had no prior evidence of GLP-1-therapy use, suggesting that early adoption included a substantial proportion of patients new to using GLP-1 medications
The severity depends on your dose, how much sugar you consume, and your individual GI sensitivity
Since clinical trials consistently show tirzepatide producing greater average weight loss than semaglutide, it might seem counterintuitive to switch in this direction