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A mystery unraveled: nontumorigenic pluripotent stem cells in human adult tissues

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In chronic liver damage, HSCs transdifferentiate from a quiescent to an activated state and are responsible for collagen deposition in the liver tissue, playing a key role in the fibrosis process

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OUTSTANDING QUESTIONS AND FUTURE DIRECTIVES Although there is a lot of evidence at present with this novel molecule, many unanswered questions remain