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What Causes Clefts
doi: 10.1016/j.phymed.2004.01.006 227 AbasFKhatibAPerumalVSuppaiahVIsmailAHamidMet al
The volume of saline added the dilution directly affects how the toxin behaves: Concentrated reconstitution (lower saline volume) smaller injection volume, less diffusion, more precise effect, but requires more accurate placement Dilute reconstitution (higher saline volume) larger injection volume, more diffusion, easier to inject but more risk of toxin spreading to unintended muscles We use a standard reconstitution of 100 units in 2.5ml of unpreserved saline a precise concentration that gives accurate dosing without excessive diffusion
Long GV, Stroyakovskiy D, Gogas H, Levchenko E, de Braud F, Larkin J, Garbe C, Jouary T, Hauschild A, Grob JJ, Chiarion Sileni V, Lebbe C, Mandala M, Millward M, Arance A, Bondarenko I, Haanen JB, Hansson J, Utikal J, Ferraresi V, Kovalenko N, Mohr P, Probachai V, Schadendorf D, Nathan P, Robert C, Ribas A, DeMarini DJ, Irani JG, Casey M, Ouellet D, Martin AM, Le N, Patel K, Flaherty K (2014) Combined BRAF and MEK inhibition versus BRAF inhibition alone in melanoma
