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SARS-CoV-2 may activate TLR4 in the heart and lungs causing aberrant TLR4 signaling favoring the proinflammatory MyD88-dependent (canonical) pathway instead of the alternative TRIF/TRAM-dependent anti-inflammatory and interferon pathway (Aboudounya and Heads, 2021)

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Zakharyuta (2018) Effect of Thymalin on the Tumor and Thymus under Conditions of Activation Therapy In Vivo Bulletin of Experimental Biology & Medicine, 2018 May, Volume 165 (Issue 1), Pages 80-83

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