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Several potential risks arise from concurrent cannabis and Wegovy use, though robust clinical trial data specifically examining this combination are currently unavailable: Reduced treatment efficacy : The most significant concern is that cannabis-induced appetite stimulation may counteract Wegovy's appetite-suppressing effects, potentially compromising weight loss outcomes

Gastrointestinal Upset: High doses can cause digestive issues like bloating for some individuals

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PloS ONE 8 , e78190 (2013)

In rare cases, a genetic condition may limit the bodys ability to produce glutathione