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Retatrutide carries no approved label yet, but the same caution applies given the class mechanism and the absence of human reproductive safety data

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Desiree Granados Editorial Process Our Editorial Process Jake Peter received his journalism degree from Emerson College and has been writing content for the Sanctuary Wellness Institute since 2021

ATTAIN-1 (NCT05869903) was a Phase III, 72-week, randomized, double-blind, placebo-controlled trial comparing the efficacy and safety of orforglipron at various doses to placebo in adults with obesity, or overweight with at least one of the following comorbidities: hypertension, dyslipidemia, obstructive sleep apnea or cardiovascular disease, who did not have diabetes