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The signals that are observed at 7.85 min in all chromatograms come from other reagents present in the sample, such as BCPB, TCEP, and PCA
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However, their efficacy has limitations, particularly in patients with morbid obesity, where they may not produce enough weight loss to control or resolve the disease fully
GLP-1RAs can downregulate the expression of the myostatin gene in C2C12 myotubes, reversing the upregulation of atrophy factors and downregulation of myogenic factors (MyoD/G) (136)
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