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Note additionally that the three methionine residues in the sequence, two of them in the N-terminal extension, make dilute standing solution vulnerable to oxidation, and that freeze-thaw cycling promotes aggregation in disulfide-bonded proteins more readily than in short peptides

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(2018) found that sertraline causes impaired the steroidogenesis of sex hormones in male rats through the direct inhibition of steroid synthesis and its indirect effects on gene expression, and plasma LH levels and LH/testosterone ratios were significantly increased, potentially triggering compensatory hypogonadism

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