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For now, the clinical interpretation is more conservative: substantial weight loss plus possible direct mechanism produced a large pain benefit in this specific population

Research has suggested that rapid weight loss from GLP-1 medications can shift fat distribution in ways that affect the sensory nerves near the skin, potentially contributing to sensations like burning, tingling, or increased sensitivity

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Tirzepatide (Mounjaro, Zepbound) Same rationale as semaglutide

Manufacturer and compounding pharmacy guidelines recommend returning unopened vials to refrigeration as soon as possible and contacting your PlexusDx provider if you're uncertain about storage conditions