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Some participants achieved weight loss of approximately 24% of body weight at 48 weeks approaching levels reported with some bariatric surgical procedures, though no direct head-to-head comparisons have been conducted and long-term durability beyond the trial period remains unknown

These pain-relieving effects are blocked by drugs that affect norepinephrine, but not serotonin, suggesting that the pain relief works through adrenergic pathways (9)

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