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In some regions, it is sold over-the-counter as a dietary supplement, while in others, it is regulated as a prescription medication or banned due to safety concerns

If a dose increase causes intolerable GI symptoms, the Phase 2 protocol explicitly permitted returning to the prior dose level and waiting a full 4 weeks before re-attempting escalation

Introduction Irritable Bowel Syndrome (IBS) is a complex, functional gastrointestinal disorder characterized by a group of symptoms that typically occur together

GPOs increasingly include supply reliability metrics in biosimilar contracting criteria alongside price

Dec 2006;77(7-8):568-573