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Recent clinical guidelines increasingly recommend GLP-1RAs for patients with type 2 diabetes who have established atherosclerotic cardiovascular disease or are at high cardiovascular risk, regardless of baseline hemoglobin A1c levels

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5,288,289 Oxidative Stress Free radicals, especially oxidized low-density lipoprotein (LDL), promote vascular inflammation, increase the expression of tissue factor on cellular surfaces, damage proteins that regulate coagulation, heighten reactivity of platelets, and disrupt antithrombotic hemostatic mechanisms, raising the risk of thrombosis

However, they note that the study still shows that these drugs do not pose a major risk of birth defects