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With respect to dosage, the average reductions were: 2000 mcg: 71.5% (single data point) 1,000 mcg: 31.8% Although limited data are available for higher dosages, the findings support the efficacy of both oral and non-oral B12 formulations in modulating homocysteine levels
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From the gut compartment, the dose first enters the liver where some of it is metabolized and conjugated, and the rest enters the general circulation from where it is taken up by liver and tissues or excreted in the urine
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