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Nausea, vomiting, diarrhea, and constipation are the most common adverse events, are generally mild to moderate, are dose-related, and cluster during the dose-escalation phase

Possible side effects include injection-site irritation, mild flushing, and occasional water retention during early cycles

It is a disruption that requires adaptation

While the drugs can lead to significant fat reduction and improved metabolic health, experts say there are important nuances to understand about how they affect muscle, metabolism and overall strength