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Studies show that Glutathione depletion is one of the earliest changes observed in neurodegenerative conditions such as Parkinsons and Alzheimers disease, where oxidative stress damages dopamine-producing neurons

The dangers come from how the treatment is delivered in the unregulated market

However, a subgroup of patients may show overlapping problems involving undermethylation, low methylation reserve, oxidative stress and impaired mitochondrial resilience

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If NMN or NR raises NAD+ enough to activate SIRT3, it could increase endogenous glutathione production independent of supplementation