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In accordance with the hypothesis that remaining EECs sustain GLP-1 expression, Pcsk1 (encoding PC1/3) expression remained unaltered under inflammation in IL-10 -/- mice, whereas expression of Dpp4 strongly decreased specifically at the site of inflammation (proximal colonic tissue) ( Figure 2G ), suggesting compensatory mechanisms to maintain GLP-1 signaling

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References KD Tripathi Essentials of Medical Pharmacology Goodman & Gilman The Pharmacological Basis of Therapeutics Review of Pharmacology Sparsh Gupta ADA Guidelines NCBI:

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