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This was followed by addition of sodium borohydride (8.7 mg, 0.23 mmol) and the mixture was allowed to warm to RT over 4 h

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The reduction of IIS in Laron subjects unmasks the potential role of persistent hyperactive IIS mediated by Western diet in the development of diseases of civilization and offers a rational perspective for dietary adjustments with less insulinotropic diets like the Paleolithic diet

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