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In the pituitary gland, DSIP co-localizes with numerous other signaling molecules including ACTH, MSH, TSH, and melanin-concentrating hormone

One participant developed pancreatitis (inflammation of the pancreas)

In one large head-to-head study, participants taking injectable semaglutide lost an average of 15% of their body weight, while those on the oral form lost just 6%

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To overcome these challenges, strategies 5 such as pH optimization, use of stabilizing excipients (buffers, antioxidants, surfactants), lyophilisation, and controlled storage conditions are employed