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Cell culture reagents, including Dulbeccos Modified Eagle Medium (DMEM) and fetal bovine serum (FBS), were obtained from Euroclone (Italy)

Mounjaro mimics the actions of both GLP-1 and GIP hormones, enhancing insulin secretion , reducing glucagon levels, and slowing gastric emptying

Leading in the GLP-1 agonist diabetes arena are Eli Lillys recently approved Mounjaro (tirzepatide) and Novo Nordisks Ozempic (semaglutide), which has been a top seller for Novo since it first launched in 2017

Activation and antitumor immunity of CD8(+) T cells are supported by the glucose transporter GLUT10 and disrupted by lactic acid