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The effect of TZDs on kidney function has been previously described in mice models (Sarafidis et al., 2010) and in a large study involving 4351 diabetic patients ( Another interesting class of hypoglycemic drugs with positive kidney outcomes are the SGLT2 inhibitors (SGLT2i) which inhibit glucose and sodium reabsorption in the PT (Williams et al., 2020)

Comparative efficacy, safety, and cardiovascular outcomes with once-weekly subcutaneous semaglutide in the treatment of type 2 diabetes: Insights from the SUSTAIN 1-7 trials

Togashi, Y