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The majority of the published literature examines each compound independently, and the synergy hypothesis, while mechanistically well-supported, has not yet been the subject of large-scale controlled studies
Pastore, A., Federici, G., Bertini, E
The bladder mucosa has a strong barrier function that prevents drugs from passing through and remaining in the bladder
However, side effects also scale with dose
For the investigation, a team led by Al-Aly sifted through the records of nearly 2 million people with diabetes who were treated by the Veterans Health Administration for an average of almost four years between October 2017 and the end of December 2023
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