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Global burden of disease (GBD): institute for health metrics and evaluation

They promote cellular rejuvenation and improve immune function

Starting weight loss therapy with uncontrolled hypothyroidism may: Confound assessment of treatment efficacy Complicate symptom attribution (fatigue, constipation overlap) Necessitate multiple medication adjustments simultaneously Practically speaking, patients may benefit from demonstrating stable thyroid function on consistent levothyroxine dosing before adding weight loss medications, though this is not a strict requirement

Mansur RB, Ahmed J, Cha DS, et al

It depends on how bad the deficiency is and how well the person responds to treatment