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3 Oxidative stress in atopic dermatitis ROS, including singlet oxygen ( 1 O 2 ), superoxide anion (O 2 ), hydroxyl radical (HO) and hydrogen peroxide (H 2 O 2 ), can cause cellular damage and have been implicated in various diseases such as psoriasis, cancer, aging, atherosclerosis (24, 4345)

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Collectively, these studies position -galactosidase-cleavable linkers as a practical intracellularly activated option within the broader family of glycosidase-sensitive ADC designs, particularly in applications where controlled, cell-restricted payload release is preferred

Do side effects multiply or synergize dangerously

Its also in Phase 3 trials and not yet FDA approved