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Baseline hormone levels: Those with lower starting GH and IGF-1 typically respond more noticeably than those with already-optimal levels

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So far from being antagonistic, biologics and GLP-1 agonists may actually have a powerful synergistic effect in which the biologic addresses the skin and joint manifestations of the disease, whilst the GLP-1 agonist reduces inflammation, improves the subjects metabolic profile and reduces body weight, thus making the individual more receptive to biologic treatment

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This delayed emptying creates prolonged feelings of fullness after meals, naturally reducing portion sizes and snacking frequency