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According to the drug's prescribing information, these potential risks are: An allergic reaction (hypersensitivity) Severe low blood sugar in people with type 2 diabetes, especially those taking insulin or sulfonylureas Complications related to diabetic retinopathy in those with type 2 diabetes Acute pancreatitis or gallbladder disease Acute kidney injury Increases in heart rate Suicidal ideation or behavior Lastly, Wegovy may increase the risk of certain thyroid tumors but this has only been observed in rodent studies

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Nicotinamide provides neuroprotection in glaucoma by protecting against mitochondrial and metabolic dysfunction