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Take semaglutide, for instance
This is called the adaptation period
Initially identified as a secreted factor induced by exercise and cold exposure, METRNL promotes energy expenditure and improves glucose tolerance through mechanisms involving immuneadipose crosstalk and beige adipocyte activation (Rao et al., 2014)
Combine it with calcium
In terms of safety and tolerability, the adverse events were primarily mild to moderate gastrointestinal reactions, with no reports of severe hypoglycemia or death
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