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FDA Approves New Drug Treatment for Chronic Weight Management, First Since 2014 2021 [Available from: Aggarwal R, Vaduganathan M, Chiu N, Bhatt DL

doi: 10.1111/pce.12003 9 ColeA

In this multicenter study conducted across 22 countries, participants (67.6% females and 72% White) received once-weekly subcutaneous administration of CagriSema ( n = 2,108) with dose escalation from 0.25 mg to a maximum of 2.4 mg for each drug, in addition to lifestyle intervention, compared with placebo ( n = 705)

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Postprandial GIP production was elevated in male but unchanged in female Tmprss2 / mice compared with WT (Figure 5C), possibly explaining the initial tendency toward increased weight gain in male Tmprss2 / versus WT mice