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TIRZEPATIDE: EFFICACY IN PHASE III CLINICAL TRIALS After the promising results in Phase I and Phase II trials, the SURPASS clinical trial programs were designed to assess the efficacy and safety of Tirzepatide as a treatment to improve glycaemic control in patients with T2D

As seen in animals, GLP-1R agonists reduce food cravings and increased brain activation to the consumption of palatable food in the right OFC of obese subjects and the left insula, bilateral putamen, left amygdala of obese patients with T2DM

pp 121126 Ahmad SF, Ansari MA, Nadeem A et al (2018) Resveratrol attenuates pro-inflammatory cytokines and activation of JAK1-STAT3 in BTBR T+ Itpr3tf/J autistic mice

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