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separately, its immune-modulating effects on T-cell and NK-cell activity, TLR-9/TLR-2 signaling, and cytokine induction are documented in more recent literature reviews

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The subject headings and text keywords included those related to the population of interest (i.e., IC, BPS), intervention (relevant treatments such as medication, instillation, intravesical injection, physical therapy and/or others), comparison (placebo or control), and outcomes of treatments: 1) individual symptoms (pain, frequency, urgency and nocturia), 2) structured questionnaires (interstitial cystitis problem index [ICPI], interstitial cystitis symptom index [ICSI], pelvic pain urgency frequency symptom scale [PUF] and functional bladder volume [FBV])