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Following the adoptive transfer, each mouse was intranasally challenged with 0.5 g rmIL-33 for 3 days prior to AHR measurements and tissue sampling being performed ( Figure 4A )
Yet another small molecule that has been studied extensively as a highly potent small molecule inhibitor of both human and murine CD38 is 78c, which has been shown to be 10-fold less potent against the cyclase activity than the hydrolase activity of recombinant human CD38 139
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The peptide was assigned three drug designations: PL-10, PLD-116, and PL14736
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