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Campbell JD, et al
In the cells, this probe is converted into dichlorodihydrofluorescein (H2DCF) that in the presence of oxidant species is oxidized into fluorescent dichlorofluorescein (DCF)
This mechanism blocks the interaction between HSC70 and GPX4, thereby preventing GPX4 degradation via chaperone-mediated autophagy in mice, inhibiting ferroptosis, and promoting tumor growth[12]
Furthermore, the life of Glutathione in serum was only 14.1 mins +/- 9 mins
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